The human skin is the outer covering of the body. In humans, it is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue and guards the underlying muscles, bones, ligaments and internal organs.[1] Human skin is similar to most of the other mammals skin, and human skin is very similar to pig skin.[2][3] Though nearly all human skin is covered with hair follicles, it can appear hairless. There are two general types of skin, hairy and glabrous skin (hairless).[4] The adjective cutaneous literally means "of the skin" (from Latin cutis, skin).
Because it interfaces with the environment, skin plays an important immunity role in protecting the body against pathogens[5] and excessive water loss.[6] Its other functions are insulation, temperature regulation, sensation, synthesis of vitamin D, and the protection of vitamin B folates. Severely damaged skin will try to heal by forming scar tissue. This is often discolored and depigmented.
In humans, skin pigmentation varies among populations, and skin type can range from dry to oily. Such skin variety provides a rich and diverse habitat for bacteria that number roughly 1000 species from 19 phyla, present on the human skin.[7][8]
The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis.[9] The dermis is tightly connected to the epidermis through a basement membrane. Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix.[10] It also contains mechanoreceptors that provide the sense of touch and thermoreceptors that provide the sense of heat. In addition, hair follicles, sweat glands, sebaceous glands, apocrine glands, lymphatic vessels and blood vessels are present in the dermis. Those blood vessels provide nourishment and waste removal for both dermal and epidermal cells.
"Skin care" (analysis), Health-Cares.net, 2007, webpage: HCcare
Herron, Alan J. (5 December 2009). "Pigs as Dermatologic Models of Human Skin Disease" (PDF). ivis.org. DVM Center for Comparative Medicine and Department of Pathology Baylor College of Medicine Houston, Texas. Retrieved 27 January 2018. pig skin has been shown to be the most similar to human skin. Pig skin is structurally similar to human epidermal thickness and dermal-epidermal thickness ratios. Pigs and humans have similar hair follicle and blood vessel patterns in the skin. Biochemically pigs contain dermal collagen and elastic content that is more similar to humans than other laboratory animals. Finally pigs have similar physical and molecular responses to various growth factors.
Liu, J., Kim, D., Brown, L., Madsen, T., Bouchard, G. F. "Comparison of Human, Porcine and Rodent Wound Healing With New Miniature Swine Study Data" (PDF). sinclairresearch.com. Sinclair Research Centre, Auxvasse, MO, USA; Veterinary Medical Diagnostic Laboratory, Columbia, MO, USA. Retrieved 27 January 2018. Pig skin is anatomically, physiologically, biochemically and immunologically similar to human skin
Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology. (4th ed.). Elsevier Inc. ISBN 1-4160-3185-5.
Proksch, E; Brandner, JM; Jensen, JM (2008). "The skin: an indispensable barrier". Experimental Dermatology. 17 (12): 1063–72. doi:10.1111/j.1600-0625.2008.00786.x. PMID 19043850.
Madison, KC. (2003). "Barrier function of the skin: "la raison d'être" of the epidermis" (PDF). J Invest Dermatol. 121 (2): 231–41. doi:10.1046/j.1523-1747.2003.12359.x. PMID 12880413.
Grice, E. A.; Kong, H. H.; Conlan, S.; Deming, C. B.; Davis, J.; Young, A. C.; Bouffard, G. G.; Blakesley, R. W.; Murray, P. R. (2009). "Topographical and Temporal Diversity of the Human Skin Microbiome". Science. 324 (5931): 1190–2. doi:10.1126/science.1171700. PMC 2805064. PMID 19478181.
Pappas S. (2009). Your Body Is a Wonderland ... of Bacteria. ScienceNOW Daily News Archived 2 June 2009 at the Wayback Machine.
James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Pages 1, 11–12. ISBN 0-7216-2921-0.
Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 8–9. ISBN 1-4160-3185-5.